Search results for " Conjugated"

showing 10 items of 20 documents

Liver carbohydrate and lipid metabolism of insulin-deficient mice is altered by trans-10, cis-12 conjugated linoleic acid.

2009

Feeding mice the trans-10, cis-12 (t10c12) conjugated linoleic acid (CLA) isomer is associated with lipodystrophy, insulin resistance, hyperinsulinemia, and liver steatosis. It has been hypothesized that CLA-induced liver steatosis is the result of increased hepatic lipogenesis stimulated by high insulin levels. We studied the effects of a 12-d t10c12CLA treatment (1 g/100 g diet) on liver carbohydrate and lipid metabolism in control and streptozotocin (STZ)-injected mice. STZ mice were characterized by insulin deficiency, hypertriglyceridemia, and depletion of liver triglyceride and glycogen. Remarkably, feeding t10c12CLA to diabetic mice (STZ-CLA) normalized these variables. Reconstitutio…

Malemedicine.medical_specialtyendocrine system diseasesmedicine.medical_treatmentMedicine (miscellaneous)BiologyDiabetes Mellitus Experimentalchemistry.chemical_compoundMiceInsulin resistanceInternal medicinemedicineAnimalsLinoleic Acids ConjugatedNutrition and DieteticsGlycogenGlucokinaseInsulinFatty livernutritional and metabolic diseasesLipid metabolismmedicine.diseaseLipid MetabolismMice Inbred C57BLEndocrinologychemistryGene Expression RegulationLiverGlycogenesisLipogenesisBody CompositionCarbohydrate Metabolismlipids (amino acids peptides and proteins)The Journal of nutrition
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Effects of Conjugated Linoleic Acid and Endurance Training on Peripheral Blood and Bone Marrow of Trained Mice

2007

Fat supplements, especially conjugated linoleic acid (CLA), are increasingly popular ergogenic aids among endurance athletes. To evaluate the importance of fat supplementation in the practice of endurance sports, we investigated the effects of CLA supplementation on body weight, muscle hypertrophy, peripheral blood composition, and bone marrow composition in healthy, young, endurance-trained mice. Young, healthy mice were subdivided into control, trained, and treated groups, according to their running attitudes. Training was performed over a period of 6 weeks on a treadmill, at a gradually increasing duration and speed. CLA-treated groups were gavaged with 0.425 mg x d(-1) CLA supplement fo…

Malelinoleic acidmedicine.medical_specialtyConjugated linoleic acidPhysical Therapy Sports Therapy and RehabilitationBone Marrow Cellsmedicine.disease_causeMuscle hypertrophychemistry.chemical_compoundMiceEndurance trainingInternal medicinePhysical Conditioning AnimalmedicineAnimalsOrthopedics and Sports MedicineLinoleic Acids ConjugatedTreadmillMuscle SkeletalAnalysis of Variancebusiness.industryBody WeightGeneral MedicineNeutrophiliaBlood Cell CountOxidative StressEndocrinologymedicine.anatomical_structurechemistryPhysical EnduranceBone marrowAnalysis of variancemedicine.symptombusinessOxidative stress
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Isomerization of 9c11t/10t12c CLA in Triacylglycerols

2010

Published version of an article in the journal: Lipids . The original publication is available at Spingerlink. http://dx.doi.org/10.1007/s11745-010-3452-x Isomers of conjugated linoleic acid from 7t9c through 12t14t can be induced by thermal treatment of triacylglycerol samples of 9c11t or 10t12c fatty acids in glass tubes. The formation of conjugated linoleic acids (CLAs) has been observed during thermal induction of the above-mentioned triacylglycerols at 250, 280 and 320A degrees C. The concentrations of isomers formed in the mixture varied depending on the temperature and duration of the heating experiments. The objective of this study was to find a suitable thermal induction temperatur…

chemistry.chemical_classificationHeptaneChromatography GasChromatographySpectrophotometry InfraredGlycerideConjugated linoleic acidOrganic Chemistryfood and beveragesFatty acidCell BiologyThermal treatmentBiochemistryAmpoulechemistry.chemical_compoundIsomerismchemistryOrganic chemistryLinoleic Acids ConjugatedGas chromatographyVDP::Mathematics and natural science: 400::Chemistry: 440::Organic chemistry: 441IsomerizationTriglycerides
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Upregulation of liver VLDL receptor and FAT/CD36 expressions in LDLR-/- apoB100/100 mice fed trans-10,cis-12 conjugated linoleic acid

2006

International audience; This study explores the mechanisms responsible for the fatty liver setup in mice fed trans-10,cis-12 conjugated linoleic acid (t10c12 CLA), hypothesizing that an induction of low density lipoprotein receptor (LDLR) expression is associated with lipid accumulation. To this end, the effects of t10c12 CLA treatment on lipid parameters, serum lipoproteins, and expression of liver lipid receptors were measured in LDLR(-/-) apoB(100/100) mice as a model of human familial hypercholesterolemia itself depleted of LDLR. Mice were fed t10c12 CLA over 2 or 4 weeks. We first observed that the treatment induced liver steatosis, even in the absence of LDLR. Mice treated for 2 weeks…

CD36 AntigensMaleVery low-density lipoproteinTRANSLOCASECD36RECEPTEUR SCAVENGER[SDV]Life Sciences [q-bio]FATTY ACID TRANSLOCASE030204 cardiovascular system & hematologyBiochemistryMice0302 clinical medicineEndocrinologyLinoleic Acids ConjugatedMice Knockout0303 health sciencesLipoprotein lipaselipoprotéinebiologyacide grasrécepteur d'hormoneChemistryFatty liverFatty Acidsfood and beveragesHEPATIC LIPASELipidsLOW DENSITY LIPOPROTEIN RECEPTOR3. Good healthUp-RegulationLiverSCAVENGER RECEPTOR CLASS B TYPE ILIVER STEATOSIS;LOW DENSITY LIPOPROTEIN RECEPTOR;TRIGLYCERIDE;LIPOATROPHY;LIPOPROTEIN;FATTY ACID TRANSLOCASE;VERY LOW DENSITY LIPOPROTEIN RECEPTOR;HEPATIC LIPASE;LIPOPROTEIN LIPASE;LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN;SCAVENGER RECEPTOR CLASS B TYPE I;LIPOATROPHIE;TRANSLOCASE;LIPASE HEPATIQUE;RECEPTEUR SCAVENGERApolipoprotein B-100lipoprotéine lipaseTRIGLYCERIDElipids (amino acids peptides and proteins)Oxidation-Reductionmedicine.medical_specialtyLIPASE HEPATIQUELipolysisVLDL receptorMice Transgenicacide linoléique conjugué03 medical and health sciencesstéatose hépatiqueInternal medicineLIVER STEATOSISmedicineLIPOPROTEIN LIPASEAnimalsRNA Messengerlipoprotéine de faible densite030304 developmental biologyLOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEINnutritional and metabolic diseasesCell Biologymedicine.diseaseLipid MetabolismLIPOATROPHYDietary FatsEndocrinologyLIPOPROTEINReceptors LDLVERY LOW DENSITY LIPOPROTEIN RECEPTORLIPOATROPHIELDL receptorbiology.proteinacide gras transHepatic lipaseLipoprotein
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Organoboron Polymers for Photovoltaic Bulk Heterojunctions

2010

SOLAR-CELLSphotovoltaic bulk heterojunctionORGANIC PHOTOVOLTAICSn-type polymerthin filmsSOLAR-CELLS; ORGANIC PHOTOVOLTAICS; CONJUGATED POLYMERSCONJUGATED POLYMERSboranehigh performance polymer
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Trans-10, cis-12 conjugated linoleic acid induced cell death in human colon cancer cells through reactive oxygen species-mediated ER stress

2013

Dietary conjugated linoleic acids (CLA) are fatty acid isomers with anticancer activities produced naturally in ruminants or from vegetable oil processing. The anticancer effects of CLA differ upon the cancer origin and the CLA isomers. In this study, we carried out to precise the effects of CLA isomers, c9,t11 and t10,c12 CLA, on mechanisms of cell death induction in colon cancer cells. We first showed that only t10,c12 CLA treatment (25 and 50μM) for 72h triggered apoptosis in colon cancer cells without affecting viability of normal-derived colon epithelial cells. Exposure of colon cancer cells to t10,c12 CLA activated ER stress characterized by induction of eIF2α phoshorylation, splicing…

Programmed cell deathConjugated linoleic acidCHOPBiologychemistry.chemical_compoundCell Line TumormedicineHumansCytotoxic T cellLinoleic Acids ConjugatedMolecular BiologyCell ProliferationCell Deathintegumentary systemReverse Transcriptase Polymerase Chain Reactionfood and beveragesCancerCell BiologyEndoplasmic Reticulum Stressmedicine.diseaseImmunohistochemistrychemistryBiochemistryCell cultureApoptosisCancer cellCancer researchlipids (amino acids peptides and proteins)Reactive Oxygen SpeciesBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
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Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue.

2006

Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Many people supplement their diets with CLAs to attempt weight loss, and the trans-10,cis-12 isomer (t10,c12-CLA) of CLA reduces adiposity in animal models and humans. However, CLA treatment in mice causes insulin resistance that has been attributed to the lipoatrophic state, which is associated with hyperinsulinemia and hepatic steatosis. Here, we investigated the effect of t10,c12-CLA on adipose tissue inflammation, another factor promoting insulin resistance. We confirmed that t10,c12-CLA daily gavage performed in mice reduces white adipose tissue (WAT) mass and adiponectin and leptin serum levels and provo…

Leptinmedicine.medical_specialtyEndocrinology Diabetes and MetabolismConjugated linoleic acidAdipose Tissue WhiteAdipose tissueInflammationEnzyme-Linked Immunosorbent AssayWhite adipose tissueBiologychemistry.chemical_compoundMiceInsulin resistanceInternal medicine3T3-L1 CellsHyperinsulinismInternal MedicinemedicineHyperinsulinemiaAnimalsLinoleic Acids ConjugatedResistinInflammationintegumentary systemAdiponectinInterleukin-6Reverse Transcriptase Polymerase Chain ReactionTumor Necrosis Factor-alphaLeptinMacrophagesNF-kappa Bfood and beveragesmedicine.diseaseImmunohistochemistryMice Inbred C57BLPPAR gammaEndocrinologychemistryDietary Supplementslipids (amino acids peptides and proteins)FemaleAdiponectinmedicine.symptomInsulin ResistanceDiabetes
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Exercise and Conjugated Linoleic Acid Supplementation Induce Changes in the Composition of Liver Fatty Acids

2019

Exercise and supplementation with conjugated linoleic acid (CLA) are used to reduce body weight and to improve health. Applied together, they may exert a synergistic effect. However, the effects of exercise and CLA supplementation on liver metabolism are poorly understood. The aim of this study was to examine the influence of exercise and CLA supplementation on fatty acids (FA) composition in mouse liver. We analyzed 44 of known FAs of this organ by gas chromatography-mass spectrometry. Our results demonstrated that exercise contributed to a decrease in odd-chain FA and an increase in n-6 polyunsaturated FA contents. In turn, CLA stimulated an increase in branched-chain FAs and n-3 polyunsa…

0301 basic medicinemedicine.medical_specialtyPhysiologyConjugated linoleic acid030209 endocrinology & metabolismHealth benefitslivermyokinelcsh:Physiologyconjugated linoleic acid03 medical and health scienceschemistry.chemical_compound0302 clinical medicineInternal medicinePhysiology (medical)MyokinemedicineFatty acid synthesisfatty acid liver exercise myokine conjugated linoleic acidchemistry.chemical_classificationlcsh:QP1-981exerciseintegumentary systemfood and beveragesFatty acidBrief Research Report030104 developmental biologyEndocrinologyEnzymeLiver metabolismchemistrylipids (amino acids peptides and proteins)Composition (visual arts)fatty acidFrontiers in Physiology
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New amphiphilic conjugates of mono- and bis(carboxy)-PEG(2,000) polymers with lipoamino acids as surface modifiers of colloidal drug carriers

2010

chemistry.chemical_classificationamphiphilesPolymers and Plasticspoly(ethylene glycol)Organic Chemistrylipoaminoacids copolymers surface modifiers drug carrierslipoamino acidslong-circulating drug-delivery systemsPolymerCondensed Matter PhysicsColloidMatrix-assisted laser desorption/ionizationchemistrySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoPolymer chemistryAmphiphileamphiphiles; conjugated polymers; lipoamino acids; long-circulating drug-delivery systems; MALDI-TOF MS; poly(ethylene glycol)Materials Chemistryconjugated polymersMALDI-TOF MSPhysical and Theoretical ChemistryDrug carrierConjugate
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Effects of Conjugated Linoleic Acid Associated With Endurance Exercise on Muscle Fibres and Peroxisome Proliferator-Activated Receptor γ Coactivator …

2016

Conjugated linoleic acid (CLA) has been reported to improve muscle hypertrophy, steroidogenesis, physical activity, and endurance capacity in mice, although the molecular mechanisms of its actions are not completely understood. The aim of the present study was to identify whether CLA alters the expression of any of the peroxisome proliferator-activated receptor γ coactivator 1α (PGC1α) isoforms, and to evaluate the possible existence of fibre-type-specific hypertrophy in the gastrocnemius and plantaris muscles. Mice were randomly assigned to one of four groups: placebo sedentary, CLA sedentary, placebo trained, or CLA trained. The CLA groups were gavaged with 35 μl per day of Tonalin® FFA 8…

MaleConjugatedPhysiologyClinical BiochemistryMuscle Fibers SkeletalMuscle FibersMiceLectinsPhysical Conditioning AnimalAnimalsProtein IsoformsLinoleic Acids ConjugatedInbred BALB CMice Inbred BALB CAnimalSettore BIO/16 - Anatomia UmanaAdenylate KinaseSkeletalCell BiologyPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhysical ConditioningHindlimbMitochondriaLinoleic AcidsAdenylate Kinase; Animals; Dietary Supplements; Hindlimb; Lectins; Linoleic Acids Conjugated; Male; Mice Inbred BALB C; Mitochondria; Muscle Fibers Skeletal; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Protein Isoforms; Physical Conditioning Animal; Physiology; Clinical Biochemistry; Cell BiologyDietary SupplementsFat supplements
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